![]() Apolipoprotein E4 status significantly modified the association between intra-individual variability in sleep efficiency and β-amyloid burden, such that less sleep efficiency variability was associated with lower β-amyloid burden in apolipoprotein E4 carriers only. Longer sleep duration was associated with better visual memory and inhibitory control. Less intra-individual variability in sleep efficiency was associated with lower β-amyloid burden, higher global cognition and better inhibitory control, but not with tau burden. Less intra-individual variability in sleep duration was associated with lower β-amyloid burden, higher global cognition and better inhibitory control, with a trend for lower tau burden. Modifying effects of apolipoprotein E4 status were also explored. To examine these relationships, we evaluated 52 older adults (age = 66.4 ± 6.89, 67% female, 27% apolipoprotein E4 carriers) with objective early mild cognitive impairment. The current cross-sectional study sought to investigate the role of intra-individual variability in accelerometer-based objective sleep duration and sleep efficiency in relation to in vivo Alzheimer’s disease pathology ( β-amyloid and tau) using positron emission tomography imaging and cognition (working memory, inhibitory control, verbal memory, visual memory and global cognition). However, studies often focus on average sleep measures, usually from self-report questionnaires, ignoring the role of intra-individual variability in sleep across nights quantified from objective sleep measures. Sleep.Both sleep duration and sleep efficiency have been associated with risk of Alzheimer’s disease, suggesting that interventions to promote optimal sleep may be a way to reduce Alzheimer’s disease risk. 0084 Napping in the morning is associated with risk of Alzheimer’s dementia in older adults. Whether restricting morning napping would reduce the risk of cognitive decline requires further studies. Napping during the morning was associated with greater risk of dementia due to Alzheimer’s disease compared to napping later in the day. However, this study highlights the significance of nap time in the risk of dementia. The duration of naps in day time increases with advancing age. However, this association was not observed for naps at other times of the day HR for naps during noon time was 1.02 for early afternoon, it was 1.28 for late afternoon and early evening, HR was 0.62. However, this association was seen to diminish after adjusting for BMI, total duration and frequency of the naps, and intradaily variability in rhythms (HR 1.71). Women who napped between 9 and 11 am were at greater risk (HR 2.22) vs men (HR 1.01). Those who napped in the morning were 2-folds more at risk of Alzheimer’s dementia compared to those who took their naps at other times with a hazard ratio (HR) of 1.93. The mean time to develop Alzheimer’s dementia was 6.34 years. The nap times were categorized as morning (9-11am), noon (11am-1pm), early afternoon (1-3pm), late afternoon (3-5pm) and early evening (5-7pm).ĭuring the follow-up period, 30% of the participants were diagnosed with Alzheimers dementia. All the participants wore an accelerometer to measure activity. They were followed up for a mean period of ~7 years for development of dementia due to Alzheimer’s disease. The study, which was also presented at SLEEP 2023, enrolled 1203 participants from the Rush Memory and Aging Project (MAP), with a mean age of 80 years 77% of the selected subjects were female. ![]() Elderly people who nap in the morning and not at other times of the day are twice more likely to develop dementia due to Alzheimers disease, according to a recent study published in the journal Sleep. ![]()
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